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學(xué)習(xí)快評(píng)丨qibao666888　　北??(bei)京??(jing)時(shí)??(shi)間??(jian)3月??(yue)25日??(ri)??，清?(qing)華??(hua)大??(da)學(xué)??(xue)藥??(yao)學(xué)??(xue)院??(yuan)丁??(ding)勝?(sheng)教??(jiao)授??(shou)團(tuán)??(tuan)隊(duì)??(dui)在??(zai)國(guó)??(guo)際??(ji)頂??(ding)級(jí)??(ji)學(xué)??(xue)術(shù)?(shu)期??(qi)刊?(kan)《Immunity》發(fā)??(fa)表??(biao)突??(tu)破??(po)性??(xing)研??(yan)究??(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的?(de)關(guān)??(guan)鍵??(jian)開??(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功??(gong)從??(cong)2400多??(duo)種??(zhong)化??(hua)合?(he)物??(wu)中??(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精??(jing)準(zhǔn)??(zhun)修??(xiu)復(fù)??(fu)該??(gai)系??(xi)統(tǒng)?(tong)的??(de)藥??(yao)物??(wu)小??(xiao)分??(fen)子?(zi)BMS265246??。??在??(zai)動(dòng)?(dong)物??(wu)實(shí)??(shi)驗(yàn)??(yan)中??(zhong)??，這??(zhe)種?(zhong)新?(xin)型??(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患?(huan)病??(bing)小?(xiao)鼠?(shu)的??(de)腦?(nao)部??(bu)炎??(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本??(ben)恢?(hui)復(fù)??(fu)正??(zheng)常??(chang)??。這?(zhe)項(xiàng)??(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學(xué)??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細(xì)?(xi)胞??(bao)周??(zhou)期?(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控??(kong)非??(fei)分??(fen)裂??(lie)細(xì)??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄??(zhan)新??(xin)的??(de)實(shí)??(shi)例??(li)??，更??(geng)為??(wei)治??(zhi)療??(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)提??(ti)供??(gong)了??(le)全??(quan)新??(xin)路??(lu)徑??(jing)??。　　研??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過?(guo)基??(ji)因?(yin)編??(bian)輯?(ji)技??(ji)術(shù)??(shu)?，在??(zai)實(shí)??(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源?(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基?(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個(gè)?(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細(xì)?(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)?，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋?(dan)白??(bai)產(chǎn)??(chan)量?(liang)銳??(rui)減??(jian)?，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異?(yi)常??(chang)活??(huo)躍??(yue)?，這?(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失?(shi)效??(xiao)??。更?(geng)糟??(zao)的??(de)是?(shi)?，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個(gè)??(ge)如??(ru)同??(tong)汽??(qi)車祝(che)“安??(an)全??(quan)鎖?(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)?，就??(jiu)會(huì)?(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)?(shi)徹?(che)底??(di)釋?(shi)放??(fang)NF-κB信??(xin)號(hào)??(hao)通??(tong)路??(lu)?，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等?(deng)炎??(yan)癥??(zheng)因??(yin)子?(zi)的?(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)?，如??(ru)同??(tong)自??(zi)動(dòng)秘(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在?(zai)速?(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)?(jin)行??(xing)加??(jia)速??(su)?，會(huì)??(hui)橫??(heng)沖??(chong)直?(zhi)撞??(zhuang)造?(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。。