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　　三九養(yǎng)生堂記者 鄧肯·蓋伊 報道

精彩|　　在??(zai)采??(cai)訪??(fang)中?(zhong)??，廖??(liao)寧??(ning)教??(jiao)授??(shou)告??(gao)訴??(su)記??(ji)者??(zhe)??，BRCA1、BRCA2是??(shi)最??(zui)常??(chang)見??(jian)的??(de)乳??(ru)腺??(xian)癌??(ai)遺??(yi)傳?(chuan)基?(ji)因??(yin)??。??國??(guo)人??(ren)乳??(ru)腺??(xian)癌??(ai)患??(huan)者??(zhe)多??(duo)出??(chu)現(xiàn)??(xian)BRCA2遺??(yi)傳??(chuan)基??(ji)因??(yin)；TP53、TBL1也??(ye)都?(dou)是?(shi)中??(zhong)國??(guo)女??(nv)性??(xing)乳??(ru)腺??(xian)癌?(ai)遺??(yi)傳??(chuan)的??(de)幾??(ji)個?(ge)重??(zhong)要??(yao)的?(de)基??(ji)因??(yin)??。她??(ta)呼??(hu)吁??(xu)??，女??(nv)性??(xing)一?(yi)生??(sheng)中??(zhong)做??(zuo)一??(yi)次??(ci)和??(he)女??(nv)性??(xing)惡??(e)性??(xing)腫??(zhong)瘤??(liu)相??(xiang)關??(guan)的??(de)遺??(yi)傳??(chuan)基??(ji)因??(yin)的??(de)檢??(jian)測??(ce)??，以?(yi)了??(le)解??(jie)自??(zi)己?(ji)罹??(li)患??(huan)乳??(ru)腺??(xian)癌??(ai)的??(de)風??(feng)險??(xian)??，進?(jin)而??(er)做?(zuo)針??(zhen)對??(dui)性??(xing)的??(de)預??(yu)防??(fang)???！　∪??(ru)今??(jin)??，靶??(ba)向?(xiang)治??(zhi)療??(liao)、免??(mian)疫??(yi)治?(zhi)療??(liao)、內??(nei)分??(fen)泌??(mi)治??(zhi)療??(liao)等??(deng)為??(wei)乳??(ru)腺??(xian)癌??(ai)患??(huan)者??(zhe)提??(ti)供??(gong)了??(le)更??(geng)精??(jing)準??(zhun)的??(de)治??(zhi)療??(liao)方??(fang)式??(shi)??。??關??(guan)于??(yu)乳??(ru)腺??(xian)癌??(ai)內??(nei)分??(fen)泌??(mi)治?(zhi)療?(liao)的??(de)耐??(nai)藥??(yao)問??(wen)題?(ti)??，廖??(liao)寧??(ning)教??(jiao)授??(shou)直??(zhi)言??(yan)：“這??(zhe)不??(bu)是??(shi)莫??(mo)名?(ming)其??(qi)妙??(miao)就??(jiu)出??(chu)現(xiàn)??(xian)的??(de)??，耐??(nai)藥??(yao)亦??(yi)有??(you)基??(ji)因??(yin)的??(de)影??(ying)響??(xiang)??。其??(qi)團??(tuan)隊??(dui)在??(zai)二??(er)代??(dai)測??(ce)序秘(xu)方??(fang)面?(mian)的??(de)研??(yan)究??(jiu)發(fā)??(fa)現(xiàn)??(xian)??，中??(zhong)國??(guo)人??(ren)最??(zui)高??(gao)的??(de)耐??(nai)藥??(yao)基??(ji)因??(yin)是??(shi)PIK3CA??，占??(zhan)了??(le)13%??，這?(zhe)與??(yu)西??(xi)方??(fang)人??(ren)群??(qun)不??(bu)同??(tong)??。TP53、KARS、TERT亦??(yi)是??(shi)導??(dao)致??(zhi)預?(yu)后??(hou)不??(bu)良?(liang)的??(de)基??(ji)因??(yin)??。她??(ta)指??(zhi)出??(chu)??，針??(zhen)對?(dui)耐?(nai)藥??(yao)??，在??(zai)基??(ji)因??(yin)檢??(jian)測??(ce)的??(de)基??(ji)礎??(chu)上??(shang)??，聯(lián)??(lian)合??(he)相??(xiang)關?(guan)抑??(yi)制??(zhi)劑??(ji)內??(nei)分??(fen)泌??(mi)治??(zhi)療??(liao)??。

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