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學(xué)習(xí)快評丨qibao666888　　北??(bei)京??(jing)時??(shi)間??(jian)3月?(yue)25日??(ri)??，清??(qing)華??(hua)大??(da)學(xué)??(xue)藥??(yao)學(xué)??(xue)院??(yuan)丁??(ding)勝??(sheng)教??(jiao)授??(shou)團(tuán)?(tuan)隊??(dui)在??(zai)國??(guo)際??(ji)頂??(ding)級??(ji)學(xué)?(xue)術(shù)??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表??(biao)突??(tu)破?(po)性??(xing)研??(yan)究??(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關(guān)??(guan)鍵??(jian)開??(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功??(gong)從??(cong)2400多??(duo)種??(zhong)化??(hua)合??(he)物??(wu)中??(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精??(jing)準(zhǔn)??(zhun)修??(xiu)復(fù)??(fu)該??(gai)系?(xi)統(tǒng)??(tong)的??(de)藥??(yao)物??(wu)小??(xiao)分??(fen)子??(zi)BMS265246??。??在??(zai)動??(dong)物??(wu)實?(shi)驗??(yan)中??(zhong)??，這??(zhe)種??(zhong)新??(xin)型??(xing)CDK2抑??(yi)制?(zhi)劑??(ji)使祝(shi)患?(huan)病??(bing)小?(xiao)鼠?(shu)的?(de)腦??(nao)部??(bu)炎??(yan)癥??(zheng)消?(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能?(neng)基??(ji)本??(ben)恢??(hui)復(fù)??(fu)正??(zheng)常??(chang)??。這??(zhe)項?(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學(xué)??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細(xì)??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控??(kong)非??(fei)分??(fen)裂?(lie)細(xì)??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄??(zhan)新??(xin)的??(de)實??(shi)例??(li)??，更??(geng)為??(wei)治?(zhi)療?(liao)十?(shi)多??(duo)種??(zhong)神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)提??(ti)供??(gong)了?(le)全??(quan)新??(xin)路??(lu)徑??(jing)???！　⊙??(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)通??(tong)過?(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實?(shi)驗?(yan)室??(shi)培??(pei)養(yǎng)??(yang)的?(de)人?(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個?(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的?(de)細(xì)??(xi)胞?(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)?(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量?(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這?(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的?(de)關(guān)??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)?(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是?(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦?(dan)缺??(que)失?(shi)??，就??(jiu)會??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激?(ji)活祝(huo)時??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼??(ji)而?(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎?(yan)癥?(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)?(yan)重??(zhong)破??(po)壞??(huai)??。。