上海交大發(fā)布蛋白質(zhì)設(shè)計(jì)模型“Venus”
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“我??(wo)們?(men)訓(xùn)??(xun)練??(lian)了??(le)Venus(啟??(qi)明??(ming)星??(xing))系??(xi)列??(lie)模??(mo)型??(xing)??,與??(yu)DeepMind團(tuán)??(tuan)隊(duì)??(dui)的??(de)AlphaFold預(yù)?(yu)測(cè)??(ce)蛋?(dan)白??(bai)質(zhì)?(zhi)結(jié)??(jie)構(gòu)??(gou)不?(bu)同??(tong)??,這??(zhe)個(gè)??(ge)模??(mo)型??(xing)學(xué)??(xue)習(xí)??(xi)自??(zi)然??(ran)界??(jie)蛋??(dan)白??(bai)質(zhì)??(zhi)序??(xu)列??(lie)的??(de)組??(zu)織??(zhi)規(guī)??(gui)則??(ze)以??(yi)及??(ji)它??(ta)與??(yu)功??(gong)能??(neng)之??(zhi)間??(jian)的?(de)關(guān)??(guan)系??(xi)??,其??(qi)預(yù)??(yu)測(cè)??(ce)蛋??(dan)白??(bai)質(zhì)??(zhi)突??(tu)變??(bian)功??(gong)能??(neng)的??(de)精??(jing)度?(du)位??(wei)居??(ju)行??(xing)業(yè)??(ye)榜??(bang)單??(dan)之??(zhi)首??(shou)?。??”洪??(hong)亮??(liang)說?(shuo)??,Venus系??(xi)列??(lie)模?(mo)型??(xing)具??(ju)備??(bei)兩??(liang)大??(da)核??(he)心??(xin)功??(gong)能??(neng):“AI定??(ding)向??(xiang)進(jìn)?(jin)化??(hua)”與??(yu)“AI挖??(wa)酶??(mei)”?。這??(zhe)些??(xie)超??(chao)常?(chang)規(guī)??(gui)功??(gong)能??(neng)的??(de)蛋??(dan)白?(bai)質(zhì)??(zhi)在??(zai)生??(sheng)物??(wu)技??(ji)術(shù)??(shu)、醫(yī)??(yi)藥??(yao)研??(yan)發(fā)??(fa)和??(he)工??(gong)業(yè)?(ye)生??(sheng)產(chǎn)??(chan)中??(zhong)具??(ju)有??(you)巨??(ju)大??(da)的??(de)應(yīng)??(ying)用??(yong)潛??(qian)力??(li)??,能??(neng)夠?(gou)為??(wei)相??(xiang)關(guān)??(guan)領(lǐng)??(ling)域??(yu)帶??(dai)來??(lai)創(chuàng)??(chuang)新??(xin)和??(he)突??(tu)破??(po)?。 蛋??(dan)白??(bai)質(zhì)??(zhi)是??(shi)由??(you)20種??(zhong)氨??(an)基??(ji)酸??(suan)組?(zu)成??(cheng)的??(de)一??(yi)條??(tiao)高??(gao)分??(fen)子??(zi)鏈??(lian)??,這??(zhe)個(gè)??(ge)高??(gao)分??(fen)子??(zi)鏈??(lian)會(huì)??(hui)扭??(niu)曲??(qu)并??(bing)折??(zhe)疊??(die)成??(cheng)獨(dú)?(du)特?(te)的??(de)三??(san)維??(wei)結(jié)??(jie)構(gòu)??(gou)??,正?(zheng)是??(shi)這??(zhe)種?(zhong)獨(dú)??(du)特??(te)結(jié)??(jie)構(gòu)??(gou)賦??(fu)予??(yu)了?(le)特??(te)定??(ding)蛋??(dan)白??(bai)質(zhì)??(zhi)的??(de)生??(sheng)物??(wu)功??(gong)能??(neng)??。??要??(yao)設(shè)??(she)計(jì)??(ji)出??(chu)一??(yi)款??(kuan)成??(cheng)功?(gong)的??(de)蛋??(dan)白??(bai)質(zhì)??(zhi)產(chǎn)??(chan)品?(pin)??,不??(bu)能??(neng)只??(zhi)關(guān)??(guan)注??(zhu)它??(ta)的?(de)三??(san)維??(wei)結(jié)??(jie)構(gòu)??(gou)??,而??(er)是??(shi)要??(yao)能??(neng)成??(cheng)功?(gong)預(yù)??(yu)測(cè)??(ce)和??(he)設(shè)??(she)計(jì)??(ji)它??(ta)的??(de)功??(gong)能??(neng)??。洪??(hong)亮??(liang)團(tuán)?(tuan)隊(duì)??(dui)直?(zhi)接??(jie)瞄??(miao)準(zhǔn)??(zhun)“功?(gong)能??(neng)預(yù)??(yu)測(cè)??(ce)”這??(zhe)一?(yi)終?(zhong)極?(ji)目??(mu)標(biāo)??(biao)??,將??(jiang)復(fù)??(fu)雜??(za)的??(de)蛋??(dan)白?(bai)質(zhì)??(zhi)設(shè)??(she)計(jì)??(ji)變??(bian)成??(cheng)以??(yi)需??(xu)求??(qiu)為??(wei)導(dǎo)??(dao)向??(xiang)??,配??(pei)合??(he)少??(shao)量??(liang)實(shí)??(shi)驗(yàn)??(yan)輸??(shu)出??(chu)結(jié)??(jie)果??(guo)的??(de)簡(jiǎn)??(jian)單??(dan)過??(guo)程??(cheng)??。SBMQCGIMPYqibao666888 “wo ??(wo)men ?(men)xun ??(xun)lian ??(lian)le ??(le)Venus(qi ??(qi)ming ??(ming)xing ??(xing))xi ??(xi)lie ??(lie)mo ??(mo)xing ??(xing)??,yu ??(yu)DeepMindtuan ??(tuan)dui ??(dui)de ??(de)AlphaFoldyu ?(yu)ce ??(ce)dan ?(dan)bai ??(bai)zhi ?(zhi)jie ??(jie)gou ??(gou)bu ?(bu)tong ??(tong)??,zhe ??(zhe)ge ??(ge)mo ??(mo)xing ??(xing)xue ??(xue)xi ??(xi)zi ??(zi)ran ??(ran)jie ??(jie)dan ??(dan)bai ??(bai)zhi ??(zhi)xu ??(xu)lie ??(lie)de ??(de)zu ??(zu)zhi ??(zhi)gui ??(gui)ze ??(ze)yi ??(yi)ji ??(ji)ta ??(ta)yu ??(yu)gong ??(gong)neng ??(neng)zhi ??(zhi)jian ??(jian)de ?(de)guan ??(guan)xi ??(xi)??,qi ??(qi)yu ??(yu)ce ??(ce)dan ??(dan)bai ??(bai)zhi ??(zhi)tu ??(tu)bian ??(bian)gong ??(gong)neng ??(neng)de ??(de)jing ??(jing)du ?(du)wei ??(wei)ju ??(ju)xing ??(xing)ye ??(ye)bang ??(bang)dan ??(dan)zhi ??(zhi)shou ??(shou)?。??”hong ??(hong)liang ??(liang)shuo ?(shuo)??,Venusxi ??(xi)lie ??(lie)mo ?(mo)xing ??(xing)ju ??(ju)bei ??(bei)liang ??(liang)da ??(da)he ??(he)xin ??(xin)gong ??(gong)neng ??(neng):“AIding ??(ding)xiang ??(xiang)jin ?(jin)hua ??(hua)”yu ??(yu)“AIwa ??(wa)mei ??(mei)”?。zhe ??(zhe)xie ??(xie)chao ??(chao)chang ?(chang)gui ??(gui)gong ??(gong)neng ??(neng)de ??(de)dan ??(dan)bai ?(bai)zhi ??(zhi)zai ??(zai)sheng ??(sheng)wu ??(wu)ji ??(ji)shu ??(shu)、yi ??(yi)yao ??(yao)yan ??(yan)fa ??(fa)he ??(he)gong ??(gong)ye ?(ye)sheng ??(sheng)chan ??(chan)zhong ??(zhong)ju ??(ju)you ??(you)ju ??(ju)da ??(da)de ??(de)ying ??(ying)yong ??(yong)qian ??(qian)li ??(li)??,neng ??(neng)gou ?(gou)wei ??(wei)xiang ??(xiang)guan ??(guan)ling ??(ling)yu ??(yu)dai ??(dai)lai ??(lai)chuang ??(chuang)xin ??(xin)he ??(he)tu ??(tu)po ??(po)?。 dan ??(dan)bai ??(bai)zhi ??(zhi)shi ??(shi)you ??(you)20zhong ??(zhong)an ??(an)ji ??(ji)suan ??(suan)zu ?(zu)cheng ??(cheng)de ??(de)yi ??(yi)tiao ??(tiao)gao ??(gao)fen ??(fen)zi ??(zi)lian ??(lian)??,zhe ??(zhe)ge ??(ge)gao ??(gao)fen ??(fen)zi ??(zi)lian ??(lian)hui ??(hui)niu ??(niu)qu ??(qu)bing ??(bing)zhe ??(zhe)die ??(die)cheng ??(cheng)du ?(du)te ?(te)de ??(de)san ??(san)wei ??(wei)jie ??(jie)gou ??(gou)??,zheng ?(zheng)shi ??(shi)zhe ??(zhe)zhong ?(zhong)du ??(du)te ??(te)jie ??(jie)gou ??(gou)fu ??(fu)yu ??(yu)le ?(le)te ??(te)ding ??(ding)dan ??(dan)bai ??(bai)zhi ??(zhi)de ??(de)sheng ??(sheng)wu ??(wu)gong ??(gong)neng ??(neng)??。??yao ??(yao)she ??(she)ji ??(ji)chu ??(chu)yi ??(yi)kuan ??(kuan)cheng ??(cheng)gong ?(gong)de ??(de)dan ??(dan)bai ??(bai)zhi ??(zhi)chan ??(chan)pin ?(pin)??,bu ??(bu)neng ??(neng)zhi ??(zhi)guan ??(guan)zhu ??(zhu)ta ??(ta)de ?(de)san ??(san)wei ??(wei)jie ??(jie)gou ??(gou)??,er ??(er)shi ??(shi)yao ??(yao)neng ??(neng)cheng ??(cheng)gong ?(gong)yu ??(yu)ce ??(ce)he ??(he)she ??(she)ji ??(ji)ta ??(ta)de ??(de)gong ??(gong)neng ??(neng)??。hong ??(hong)liang ??(liang)tuan ?(tuan)dui ??(dui)zhi ?(zhi)jie ??(jie)miao ??(miao)zhun ??(zhun)“gong ?(gong)neng ??(neng)yu ??(yu)ce ??(ce)”zhe ??(zhe)yi ?(yi)zhong ?(zhong)ji ?(ji)mu ??(mu)biao ??(biao)??,jiang ??(jiang)fu ??(fu)za ??(za)de ??(de)dan ??(dan)bai ?(bai)zhi ??(zhi)she ??(she)ji ??(ji)bian ??(bian)cheng ??(cheng)yi ??(yi)xu ??(xu)qiu ??(qiu)wei ??(wei)dao ??(dao)xiang ??(xiang)??,pei ??(pei)he ??(he)shao ??(shao)liang ??(liang)shi ??(shi)yan ??(yan)shu ??(shu)chu ??(chu)jie ??(jie)guo ??(guo)de ??(de)jian ??(jian)dan ??(dan)guo ??(guo)cheng ??(cheng)??。