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學習快評丨qibao666888　　研??(yan)究??(jiu)團??(tuan)隊?(dui)培??(pei)育??(yu)了??(le)具??(ju)有??(you)自??(zi)閉??(bi)癥??(zheng)樣?(yang)癥??(zheng)狀??(zhuang)的??(de)MEF2C缺?(que)陷?(xian)小??(xiao)鼠??(shu)??。??這??(zhe)些??(xie)小??(xiao)鼠??(shu)不??(bu)僅??(jin)表??(biao)現(xiàn)??(xian)出??(chu)嚴??(yan)重??(zhong)的??(de)社??(she)交??(jiao)障??(zhang)礙??(ai)??，在??(zai)水??(shui)迷??(mi)宮??(gong)測??(ce)試??(shi)中??(zhong)也??(ye)頻??(pin)頻??(pin)迷??(mi)失??(shi)方??(fang)向??(xiang)??。經??(jing)過??(guo)8周??(zhou)使??(shi)用??(yong)BMS265246治??(zhi)療??(liao)??，這??(zhe)群??(qun)小??(xiao)鼠??(shu)腦??(nao)部??(bu)的??(de)炎??(yan)癥??(zheng)因??(yin)子??(zi)風??(feng)暴??(bao)消??(xiao)退??(tui)??，開??(kai)始??(shi)主??(zhu)動?(dong)嗅??(xiu)探??(tan)同??(tong)伴??(ban)??，尋祝(xun)找??(zhao)水??(shui)迷??(mi)宮??(gong)平??(ping)臺??(tai)的??(de)速??(su)度??(du)顯??(xian)著??(zhu)提??(ti)升??(sheng)??。實??(shi)驗??(yan)顯??(xian)示??(shi)??，藥??(yao)物??(wu)對??(dui)小??(xiao)鼠??(shu)沒??(mei)有?(you)造??(zao)成??(cheng)體??(ti)重??(zhong)減??(jian)輕??(qing)、脫??(tuo)發(fā)??(fa)、血?(xue)液??(ye)學??(xue)毒??(du)性??(xing)等??(deng)損??(sun)傷??(shang)???！　”??(bei)京??(jing)時??(shi)間??(jian)3月??(yue)25日??(ri)??，清??(qing)華?(hua)大??(da)學??(xue)藥??(yao)學??(xue)院??(yuan)丁??(ding)勝??(sheng)教??(jiao)授?(shou)團??(tuan)隊??(dui)在??(zai)國??(guo)際??(ji)頂??(ding)級??(ji)學??(xue)術??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表??(biao)突??(tu)破??(po)性??(xing)研??(yan)究??(jiu)??，首??(shou)次??(ci)揭??(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關??(guan)鍵??(jian)開??(kai)關??(guan)??，并??(bing)成??(cheng)功?(gong)從??(cong)2400多??(duo)種??(zhong)化??(hua)合??(he)物??(wu)中??(zhong)篩??(shai)選??(xuan)出??(chu)能??(neng)精??(jing)準??(zhun)修??(xiu)復??(fu)該??(gai)系??(xi)統(tǒng)?(tong)的??(de)藥??(yao)物??(wu)小??(xiao)分??(fen)子??(zi)BMS265246??。??在??(zai)動??(dong)物??(wu)實??(shi)驗??(yan)中??(zhong)??，這??(zhe)種??(zhong)新??(xin)型?(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患??(huan)病??(bing)小??(xiao)鼠??(shu)的??(de)腦??(nao)部??(bu)炎??(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本??(ben)恢?(hui)復??(fu)正??(zheng)常??(chang)??。這??(zhe)項??(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學??(xue)界??(jie)深??(shen)入??(ru)理??(li)解??(jie)細??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調??(tiao)控??(kong)非??(fei)分??(fen)裂??(lie)細??(xi)胞??(bao)功?(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄?(zhan)新??(xin)的??(de)實??(shi)例??(li)??，更??(geng)為??(wei)治??(zhi)療??(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經??(jing)疾??(ji)病??(bing)提??(ti)供??(gong)了??(le)全??(quan)新??(xin)路??(lu)徑??(jing)??。。