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學(xué)習(xí)快評(píng)丨qibao666888　　研?(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過(guò)??(guo)基??(ji)因?(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)??(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中?(zhong)敲??(qiao)除??(chu)MEF2C基??(ji)因??(yin)??。?失??(shi)去??(qu)這??(zhe)個(gè)??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系?(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之秘(zhi)陷?(xian)入??(ru)混??(hun)亂?(luan)??，負(fù)??(fu)責(zé)??(ze)抑?(yi)制??(zhi)過(guò)??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而?(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這?(zhe)就??(jiu)好??(hao)比??(bi)控?(kong)速??(su)系??(xi)統(tǒng)?(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟?(zao)的?(de)是??(shi)??，CDK2的??(de)過(guò)??(guo)度??(du)活??(huo)躍?(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個(gè)?(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵??(jian)分??(fen)子??(zi)一?(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時(shí)??(shi)徹??(che)底??(di)釋??(shi)放??(fang)NF-κB信??(xin)號(hào)?(hao)通??(tong)路??(lu)??，繼?(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子?(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動(dòng)??(dong)駕??(jia)駛??(shi)汽?(qi)車??(che)在??(zai)速??(su)控??(kong)系?(xi)統(tǒng)??(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)??(jin)行??(xing)加??(jia)速?(su)??，會(huì)??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)?(yan)重?(zhong)破??(po)壞??(huai)??。　　正??(zheng)常??(chang)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)像??(xiang)紀(jì)??(ji)律??(lv)嚴(yán)??(yan)明??(ming)的??(de)“衛(wèi)??(wei)兵??(bing)”??，保??(bao)障??(zhang)了??(le)大?(da)腦??(nao)中??(zhong)正??(zheng)常?(chang)的??(de)神??(shen)經(jīng)??(jing)活?(huo)動(dòng)??(dong)?。??MEF2C缺??(que)失??(shi)的??(de)細(xì)祝(xi)胞?(bao)則?(ze)會(huì)??(hui)轉(zhuǎn)?(zhuan)變??(bian)為??(wei)“暴??(bao)徒?(tu)”??，對(duì)??(dui)神??(shen)經(jīng)??(jing)系??(xi)統(tǒng)??(tong)造??(zao)成??(cheng)巨??(ju)大??(da)破??(po)壞?(huai)??，分??(fen)泌??(mi)的??(de)炎??(yan)癥?(zheng)物??(wu)質(zhì)?(zhi)在??(zai)正??(zheng)常??(chang)水??(shui)平??(ping)的??(de)3倍?(bei)以??(yi)上??(shang)??，這??(zhe)復(fù)??(fu)現(xiàn)??(xian)了??(le)自??(zi)閉?(bi)癥??(zheng)患??(huan)者??(zhe)腦??(nao)部??(bu)的??(de)典?(dian)型?(xing)病??(bing)理??(li)特??(te)征?(zheng)?。。