三九養(yǎng)生堂記者 鄧肯·蓋伊 報道
精彩| 針??(zhen)對??(dui)這??(zhe)一??(yi)問??(wen)題??(ti)?，該??(gai)研?(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)研??(yan)發(fā)??(fa)的??(de)CRAQ通??(tong)過??(guo)將??(jiang)原?(yuan)始??(shi)測??(ce)序?(xu)序?(xu)列??(lie)比??(bi)對??(dui)到??(dao)組?(zu)裝??(zhuang)的??(de)基??(ji)因??(yin)組??(zu)上??(shang)?，基??(ji)于??(yu)序??(xu)列??(lie)比??(bi)對?(dui)產(chǎn)??(chan)生??(sheng)的??(de)有??(you)效??(xiao)“剪??(jian)切??(qie)對??(dui)齊??(qi)”信??(xin)息??(xi)?，可??(ke)精??(jing)準(zhǔn)?(zhun)地??(di)檢??(jian)測??(ce)基??(ji)因??(yin)組??(zu)中??(zhong)存??(cun)在??(zai)的??(de)組??(zu)裝??(zhuang)錯??(cuo)誤??(wu)??。??結(jié)?(jie)合??(he)長??(chang)讀??(du)長??(chang)測??(ce)序?(xu)片??(pian)段??(duan)和??(he)短?(duan)讀??(du)長??(chang)測??(ce)序??(xu)片??(pian)段?(duan)與??(yu)基??(ji)因??(yin)組??(zu)比??(bi)對??(dui)的??(de)特??(te)征??(zheng)?，CRAQ可??(ke)以??(yi)識??(shi)別??(bie)基??(ji)因??(yin)組??(zu)內(nèi)??(nei)小??(xiao)規(guī)??(gui)模??(mo)的??(de)區(qū)??(qu)域??(yu)組??(zu)裝??(zhuang)錯??(cuo)誤??(wu)和??(he)大??(da)范??(fan)圍??(wei)的??(de)結(jié)??(jie)構(gòu)??(gou)組??(zu)裝??(zhuang)錯??(cuo)誤??(wu)?，不??(bu)同?(tong)類??(lei)別??(bie)的?(de)錯??(cuo)誤??(wu)數(shù)??(shu)量??(liang)經(jīng)??(jing)過??(guo)統(tǒng)??(tong)計??(ji)和??(he)標(biāo)??(biao)準(zhǔn)??(zhun)化??(hua)處??(chu)理??(li)后??(hou)被??(bei)轉(zhuǎn)??(zhuan)化??(hua)為??(wei)兩??(liang)個??(ge)組??(zu)裝??(zhuang)質(zhì)?(zhi)量??(liang)評??(ping)估??(gu)指??(zhi)標(biāo)??(biao)?，以??(yi)反??(fan)映??(ying)不??(bu)同??(tong)層?(ceng)面??(mian)的??(de)基??(ji)因??(yin)組??(zu)組??(zu)裝??(zhuang)質(zhì)??(zhi)量??(liang)???！ ≌??(lun)文??(wen)通??(tong)訊??(xun)作??(zuo)者??(zhe)焦??(jiao)遠(yuǎn)??(yuan)年??(nian)研??(yan)究??(jiu)員??(yuan)指??(zhi)出??(chu)??，高??(gao)質(zhì)??(zhi)量?(liang)的??(de)參??(can)考??(kao)基??(ji)因?(yin)組??(zu)序??(xu)列??(lie)對??(dui)于??(yu)基??(ji)因??(yin)注??(zhu)釋??(shi)和??(he)相??(xiang)關(guān)??(guan)功??(gong)能??(neng)研?(yan)究??(jiu)至??(zhi)關(guān)??(guan)重??(zhong)要??(yao)??，也??(ye)是??(shi)大??(da)規(guī)??(gui)模??(mo)比??(bi)較??(jiao)基??(ji)因??(yin)組??(zu)學(xué)??(xue)和??(he)表??(biao)觀??(guan)遺??(yi)傳??(chuan)調(diào)??(tiao)控??(kong)研??(yan)究??(jiu)的??(de)重?(zhong)要??(yao)前??(qian)提??(ti)??。??不??(bu)過??(guo)??，目??(mu)前??(qian)多??(duo)數(shù)??(shu)基??(ji)因??(yin)組??(zu)序??(xu)列??(lie)中??(zhong)仍??(reng)然??(ran)存??(cun)在??(zai)一??(yi)些??(xie)組??(zu)裝??(zhuang)錯??(cuo)誤?(wu)??，給??(gei)相??(xiang)關(guān)??(guan)研??(yan)究??(jiu)帶??(dai)來??(lai)一??(yi)定??(ding)程??(cheng)度??(du)影??(ying)響??(xiang)??。而??(er)精??(jing)準(zhǔn)??(zhun)區(qū)??(qu)分??(fen)和?(he)鑒??(jian)定?(ding)高??(gao)質(zhì)??(zhi)量??(liang)與??(yu)低??(di)質(zhì)??(zhi)量?(liang)的??(de)基??(ji)因??(yin)組??(zu)序?(xu)列?(lie)??，不??(bu)僅??(jin)可??(ke)以??(yi)為??(wei)基??(ji)因??(yin)組??(zu)組?(zu)裝??(zhuang)質(zhì)??(zhi)量??(liang)提?(ti)供??(gong)評?(ping)估??(gu)依??(yi)據(jù)??(ju)和??(he)進(jìn)??(jin)一??(yi)步??(bu)改??(gai)進(jìn)??(jin)提??(ti)供??(gong)靶??(ba)點(diǎn)??(dian)??，也??(ye)可??(ke)以??(yi)為??(wei)后??(hou)期??(qi)比??(bi)較??(jiao)基??(ji)因??(yin)組?(zu)和??(he)功??(gong)能??(neng)研??(yan)究??(jiu)位??(wei)點(diǎn)??(dian)提??(ti)供??(gong)基??(ji)因??(yin)組??(zu)序??(xu)列??(lie)質(zhì)??(zhi)量??(liang)認(rèn)??(ren)證??(zheng)??。當(dāng)?(dang)前??(qian)??，雖??(sui)然??(ran)已??(yi)有??(you)一??(yi)些??(xie)基??(ji)因??(yin)組??(zu)組??(zu)裝??(zhuang)質(zhì)??(zhi)量??(liang)評??(ping)估??(gu)的??(de)方??(fang)法??(fa)和?(he)指??(zhi)標(biāo)?(biao)??，但??(dan)其??(qi)大??(da)多??(duo)僅?(jin)提??(ti)供??(gong)一??(yi)個??(ge)總??(zong)體??(ti)的??(de)評??(ping)估??(gu)值?(zhi)??，沒??(mei)有??(you)針??(zhen)對??(dui)特??(te)定?(ding)區(qū)??(qu)域??(yu)或??(huo)堿??(jian)基??(ji)的??(de)評??(ping)估??(gu)信?(xin)息??(xi)??。
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