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學(xué)習(xí)快評丨qibao666888　　北??(bei)京??(jing)時??(shi)間??(jian)3月??(yue)25日??(ri)??，清??(qing)華??(hua)大??(da)學(xué)??(xue)藥??(yao)學(xué)??(xue)院??(yuan)丁??(ding)勝??(sheng)教??(jiao)授??(shou)團??(tuan)隊??(dui)在??(zai)國??(guo)際??(ji)頂??(ding)級??(ji)學(xué)??(xue)術(shù)??(shu)期??(qi)刊??(kan)《Immunity》發(fā)??(fa)表??(biao)突??(tu)破??(po)性??(xing)研??(yan)究??(jiu)??，首??(shou)次??(ci)揭?(jie)示??(shi)控??(kong)制??(zhi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細?(xi)胞??(bao)“加??(jia)速??(su)—控??(kong)速??(su)”平??(ping)衡??(heng)的??(de)關(guān)??(guan)鍵??(jian)開??(kai)關(guān)??(guan)??，并??(bing)成??(cheng)功??(gong)從??(cong)2400多?(duo)種??(zhong)化??(hua)合??(he)物??(wu)中??(zhong)篩??(shai)選??(xuan)出??(chu)能?(neng)精??(jing)準??(zhun)修??(xiu)復(fù)??(fu)該?(gai)系??(xi)統(tǒng)??(tong)的?(de)藥??(yao)物?(wu)小??(xiao)分??(fen)子??(zi)BMS265246??。??在?(zai)動??(dong)物??(wu)實??(shi)驗??(yan)中??(zhong)??，這??(zhe)種??(zhong)新??(xin)型??(xing)CDK2抑??(yi)制??(zhi)劑??(ji)使??(shi)患??(huan)病??(bing)小??(xiao)鼠??(shu)的??(de)腦??(nao)部??(bu)炎??(yan)癥??(zheng)消??(xiao)退??(tui)??，社??(she)交??(jiao)和??(he)記??(ji)憶??(yi)功??(gong)能??(neng)基??(ji)本??(ben)恢??(hui)復(fù)??(fu)正??(zheng)常??(chang)??。這??(zhe)項??(xiang)發(fā)??(fa)現(xiàn)??(xian)不??(bu)僅??(jin)為??(wei)學(xué)??(xue)界??(jie)深??(shen)入?(ru)理??(li)解??(jie)細??(xi)胞??(bao)周??(zhou)期??(qi)蛋??(dan)白??(bai)調(diào)??(tiao)控??(kong)非??(fei)分??(fen)裂??(lie)細??(xi)胞??(bao)功??(gong)能??(neng)提??(ti)供??(gong)了??(le)嶄??(zhan)新??(xin)的??(de)實??(shi)例??(li)??，更??(geng)為?(wei)治?(zhi)療??(liao)十??(shi)多??(duo)種??(zhong)神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)提??(ti)供?(gong)了??(le)全??(quan)新??(xin)路??(lu)徑??(jing)???！　≡?(zai)丁??(ding)勝??(sheng)看??(kan)來??(lai)?，過??(guo)去??(qu)30年??(nian)?，神??(shen)經(jīng)??(jing)疾??(ji)病??(bing)藥??(yao)物??(wu)研??(yan)發(fā)??(fa)就?(jiu)像??(xiang)在??(zai)黑??(hei)暗??(an)中?(zhong)用??(yong)獵??(lie)槍??(qiang)打??(da)靶??(ba)?，“而??(er)我??(wo)們??(men)的??(de)發(fā)??(fa)現(xiàn)??(xian)是??(shi)為??(wei)這??(zhe)把??(ba)獵??(lie)槍??(qiang)提??(ti)供??(gong)了?(le)紅?(hong)外??(wai)瞄??(miao)準??(zhun)鏡??(jing)??。??CDK2是??(shi)精??(jing)確??(que)到??(dao)分??(fen)子??(zi)坐??(zuo)標??(biao)的??(de)治??(zhi)療??(liao)靶??(ba)點??(dian)?，藥??(yao)物?(wu)小??(xiao)分??(fen)子??(zi)BMS265246則??(ze)是??(shi)為??(wei)此??(ci)定??(ding)制?(zhi)的??(de)子??(zi)彈??(dan)”??。。