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學(xué)習(xí)快評(píng)丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊(duì)??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實(shí)??(shi)驗(yàn)??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中?(zhong)敲??(qiao)除?(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去??(qu)這??(zhe)個(gè)??(ge)“車??(che)速??(su)控??(kong)制?(zhi)系??(xi)統(tǒng)??(tong)核?(he)心??(xin)元??(yuan)件??(jian)”的??(de)細(xì)??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入?(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑?(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被?(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻?(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動(dòng)??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活?(huo)躍?(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個(gè)??(ge)如??(ru)同??(tong)汽??(qi)車??(che)“安?(an)全??(quan)鎖??(suo)”的??(de)關(guān)??(guan)鍵?(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會(huì)??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激?(ji)活??(huo)時(shí)??(shi)徹??(che)底??(di)釋?(shi)放??(fang)NF-κB信??(xin)號(hào)?(hao)通??(tong)路?(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子?(zi)的?(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自?(zi)動(dòng)?(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)?(tong)失??(shi)靈??(ling)時(shí)??(shi)進(jìn)??(jin)行??(xing)加??(jia)速??(su)??，會(huì)??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。　　“想??(xiang)象??(xiang)一??(yi)下??(xia)??，如?(ru)果??(guo)自??(zi)動(dòng)??(dong)駕??(jia)駛??(shi)中??(zhong)的?(de)汽??(qi)車??(che)控??(kong)速??(su)系??(xi)統(tǒng)??(tong)失?(shi)靈??(ling)??，加??(jia)速??(su)時(shí)??(shi)會(huì)??(hui)發(fā)??(fa)生??(sheng)什??(shen)么??(me)？??”丁??(ding)勝??(sheng)用??(yong)比??(bi)喻??(yu)解??(jie)釋??(shi)團(tuán)??(tuan)隊(duì)??(dui)的?(de)發(fā)??(fa)現(xiàn)??(xian)??，“MEF2C基??(ji)因?(yin)就??(jiu)是??(shi)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)行??(xing)駛??(shi)速??(su)度??(du)控??(kong)制??(zhi)的??(de)核??(he)心??(xin)元??(yuan)件??(jian)之??(zhi)一??(yi)??，它??(ta)通?(tong)過??(guo)一?(yi)套??(tao)精??(jing)密??(mi)的??(de)蛋??(dan)白??(bai)質(zhì)??(zhi)控??(kong)制?(zhi)系??(xi)統(tǒng)??(tong)維??(wei)持??(chi)免??(mian)疫??(yi)平?(ping)衡??(heng)??。?”。