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學(xué)習(xí)快評丨qibao666888　　研??(yan)究??(jiu)團(tuán)??(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編?(bian)輯??(ji)技??(ji)術(shù)??(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人?(ren)源??(yuan)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)中??(zhong)敲??(qiao)除?(chu)MEF2C基??(ji)因??(yin)??。??失??(shi)去?(qu)這??(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統(tǒng)??(tong)核??(he)心??(xin)元??(yuan)件??(jian)”的?(de)細(xì)??(xi)胞??(bao)隨?(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負(fù)??(fu)責(zé)??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應(yīng)??(ying)的??(de)p21蛋??(dan)白??(bai)產(chǎn)??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被?(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍??(yue)??，這??(zhe)就??(jiu)好??(hao)比??(bi)控??(kong)速??(su)系?(xi)統(tǒng)??(tong)的??(de)關(guān)??(guan)鍵??(jian)制??(zhi)動?(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度??(du)活??(huo)躍??(yue)直??(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如?(ru)同??(tong)汽??(qi)車??(che)“安??(an)全??(quan)鎖秘(suo)”的?(de)關(guān)??(guan)鍵??(jian)分?(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失??(shi)??，就??(jiu)會??(hui)在??(zai)小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)被??(bei)激??(ji)活??(huo)時??(shi)徹??(che)底??(di)釋??(shi)放?(fang)NF-κB信??(xin)號?(hao)通??(tong)路??(lu)??，繼??(ji)而??(er)引??(yin)發(fā)??(fa)TNF-α、IL-6等??(deng)炎??(yan)癥?(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同??(tong)自??(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在??(zai)速??(su)控??(kong)系??(xi)統(tǒng)??(tong)失??(shi)靈?(ling)時??(shi)進(jìn)??(jin)行??(xing)加?(jia)速??(su)??，會??(hui)橫?(heng)沖??(chong)直??(zhi)撞??(zhuang)造?(zao)成??(cheng)嚴(yán)??(yan)重??(zhong)破??(po)壞??(huai)??。　　中??(zhong)新??(xin)網(wǎng)??(wang)北??(bei)京??(jing)3月?(yue)26日??(ri)電??(dian) 如??(ru)果??(guo)把??(ba)大??(da)腦??(nao)比??(bi)作??(zuo)處??(chu)于??(yu)精??(jing)密??(mi)運??(yun)轉(zhuǎn)?(zhuan)中??(zhong)的??(de)自??(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)?，小??(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)就??(jiu)像??(xiang)是?(shi)車??(che)上??(shang)關(guān)??(guan)鍵?(jian)的??(de)“智??(zhi)能??(neng)車??(che)載??(zai)維?(wei)保??(bao)系??(xi)統(tǒng)??(tong)”??。??當(dāng)??(dang)其??(qi)中??(zhong)的??(de)核??(he)心?(xin)原??(yuan)件??(jian)——MEF2C基??(ji)因??(yin)出??(chu)現(xiàn)??(xian)故??(gu)障??(zhang)時??(shi)?，原??(yuan)本??(ben)的??(de)保??(bao)護(hù)??(hu)機(jī)??(ji)制??(zhi)就??(jiu)會??(hui)陷??(xian)入??(ru)混??(hun)亂??(luan)?，如??(ru)同??(tong)汽?(qi)車??(che)的??(de)控祝(kong)速?(su)系??(xi)統(tǒng)??(tong)失??(shi)靈??(ling)?，會??(hui)在??(zai)加??(jia)速??(su)時??(shi)失??(shi)控??(kong)、速??(su)度??(du)飆??(biao)升??(sheng)??。此??(ci)時?(shi)小?(xiao)膠??(jiao)質(zhì)??(zhi)細(xì)??(xi)胞??(bao)切??(qie)換??(huan)到??(dao)“狂??(kuang)飆??(biao)”模??(mo)式??(shi)?，引??(yin)發(fā)??(fa)神??(shen)經(jīng)??(jing)炎??(yan)癥??(zheng)?，這??(zhe)便??(bian)是??(shi)自??(zi)閉??(bi)癥??(zheng)、阿??(e)爾??(er)茨??(ci)海??(hai)默??(mo)病??(bing)等??(deng)腦??(nao)疾??(ji)病?(bing)的??(de)重?(zhong)要??(yao)成??(cheng)因??(yin)??。。