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學習快評丨qibao666888　　正??(zheng)常??(chang)小?(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)像?(xiang)紀??(ji)律??(lv)嚴??(yan)明??(ming)的??(de)“衛(wèi)??(wei)兵??(bing)”??，保??(bao)障??(zhang)了??(le)大??(da)腦??(nao)中??(zhong)正??(zheng)常??(chang)的??(de)神?(shen)經??(jing)活??(huo)動??(dong)??。??MEF2C缺?(que)失??(shi)的??(de)細??(xi)胞??(bao)則?(ze)會??(hui)轉??(zhuan)變??(bian)為??(wei)“暴??(bao)徒?(tu)”??，對??(dui)神??(shen)經??(jing)系??(xi)統??(tong)造??(zao)成??(cheng)巨??(ju)大??(da)破??(po)壞??(huai)??，分??(fen)泌?(mi)的??(de)炎??(yan)癥??(zheng)物??(wu)質??(zhi)在??(zai)正??(zheng)常?(chang)水??(shui)平??(ping)的??(de)3倍??(bei)以??(yi)上??(shang)??，這??(zhe)復??(fu)現??(xian)了??(le)自??(zi)閉?(bi)癥??(zheng)患??(huan)者??(zhe)腦??(nao)部??(bu)的??(de)典??(dian)型??(xing)病??(bing)理??(li)特??(te)征??(zheng)??。　　研??(yan)究??(jiu)團??(tuan)隊??(dui)通??(tong)過??(guo)基??(ji)因??(yin)編??(bian)輯??(ji)技??(ji)術??(shu)??，在??(zai)實??(shi)驗??(yan)室??(shi)培??(pei)養(yǎng)??(yang)的??(de)人??(ren)源??(yuan)小??(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)中??(zhong)敲??(qiao)除?(chu)MEF2C基??(ji)因?(yin)??。??失??(shi)去??(qu)這??(zhe)個??(ge)“車??(che)速??(su)控??(kong)制??(zhi)系??(xi)統??(tong)核?(he)心??(xin)元?(yuan)件??(jian)”的?(de)細??(xi)胞??(bao)隨??(sui)之??(zhi)陷??(xian)入??(ru)混??(hun)亂??(luan)??，負??(fu)責??(ze)抑??(yi)制??(zhi)過??(guo)度??(du)反??(fan)應??(ying)的??(de)p21蛋??(dan)白??(bai)產??(chan)量??(liang)銳??(rui)減??(jian)??，而??(er)本??(ben)該??(gai)被??(bei)約??(yue)束??(shu)的??(de)CDK2激??(ji)酶??(mei)卻??(que)異??(yi)常??(chang)活??(huo)躍?(yue)??，這??(zhe)就??(jiu)好??(hao)比?(bi)控??(kong)速??(su)系??(xi)統??(tong)的??(de)關??(guan)鍵??(jian)制??(zhi)動??(dong)環(huán)??(huan)節(jié)??(jie)失??(shi)效??(xiao)??。更??(geng)糟??(zao)的??(de)是??(shi)??，CDK2的??(de)過??(guo)度?(du)活??(huo)躍??(yue)直?(zhi)接??(jie)摧??(cui)毀??(hui)了??(le)RB蛋??(dan)白??(bai)??。這??(zhe)個??(ge)如??(ru)同??(tong)汽?(qi)車??(che)“安??(an)全?(quan)鎖??(suo)”的??(de)關??(guan)鍵??(jian)分??(fen)子??(zi)一??(yi)旦??(dan)缺??(que)失?(shi)??，就??(jiu)會??(hui)在?(zai)小?(xiao)膠??(jiao)質??(zhi)細??(xi)胞??(bao)被??(bei)激??(ji)活?(huo)時?(shi)徹??(che)底??(di)釋?(shi)放?(fang)NF-κB信??(xin)號??(hao)通??(tong)路??(lu)??，繼?(ji)而??(er)引??(yin)發(fā)?(fa)TNF-α、IL-6等??(deng)炎??(yan)癥??(zheng)因??(yin)子??(zi)的??(de)大??(da)規(guī)??(gui)模??(mo)爆??(bao)發(fā)??(fa)??，如??(ru)同?(tong)自?(zi)動??(dong)駕??(jia)駛??(shi)汽??(qi)車??(che)在?(zai)速??(su)控??(kong)系?(xi)統??(tong)失??(shi)靈??(ling)時??(shi)進??(jin)行??(xing)加??(jia)速??(su)??，會??(hui)橫??(heng)沖??(chong)直??(zhi)撞??(zhuang)造??(zao)成??(cheng)嚴??(yan)重??(zhong)破??(po)壞??(huai)??。。